Éditorial: Au fou

Éditorial: Lettre ouverte, pieds mouillés, au Président

1 CONCEPT CALCULUS : universes

This is the second paper on Concept Calculus, following the first paper that treats Better Than and Much Better Than. Concept Calculus investigates basic formal systems arising from informal commonsense thinking, establishing interpretability relations with a range of formal systems from mathematical logic. Here we focus on commonsense notions of universe, plenitude, and explosion. Interpretati...

5-Formyluracil-induced perturbations of DNA function.

Oxidation of the thymine methyl group can generate 5-formyluracil (FoU), which is known to be both mutagenic and chemically unstable in DNA. Synthetic oligonucleotides containing FoU at defined sites have been prepared to investigate potential mechanisms by which FoU might perturb DNA function. The half-life of the glycosidic bond of an FoU residue in single-stranded DNA under physiological con...

Techniques for Computing Fitness of Use (FoU) for Time Series Datasets with Applications in the Geospatial Domain

Time series data are widely used in many applications including critical decision support systems. The goodness of the dataset, called the Fitness of Use (FoU), used in the analysis has direct bearing on the quality of the information and knowledge generated and hence on the quality of the decisions based on them. Unlike traditional quality of data which is independent of the application in whi...

Identification of repair enzymes for 5-formyluracil in DNA. Nth, Nei, and MutM proteins of Escherichia coli.

5-Formyluracil (5-foU) is a potentially mutagenic lesion of thymine produced in DNA by ionizing radiation and various chemical oxidants. Although 5-foU has been reported to be removed from DNA by Escherichia coli AlkA protein in vitro, its repair mechanisms are not fully understood. In this study, we used the borohydride trapping assay to detect and characterize repair activities for 5-foU in E...